What if the Democratic Party fractured again like it did in the 1860s?

In the 1860s, under the pressure of slavery and questions related to its future, and the divide between nominees for national offices and their opinion on it, the Democratic Party fractured into Northern and Southern contingents ultimately costing them the Election of 1860.

What if the current Democratic Party fractured, in the next 12 years or three presidential election cycles, into conservative and more radical factions?