16-node Storage Spaces Direct (S2D)

I'm planning to implement a 16-node Storage Spaces Direct (S2D) cluster and would like to gather expert insights from the community. Specifically, I want to understand how data resilience is managed in such a configuration: how many node or disk failures can the system withstand before data loss becomes a concern? What are the best practices for architecting this setup to ensure optimal performance and reliability? What critical factors should be considered during planning and deployment to mitigate issues and enhance system stability? Any insights, experiences, or best practices would be greatly appreciated!