Is Sasuke genetically weak?

I’m mostly saying this because there was a point in the story where he was a normal uchiha and while he was doing well there were certain people who powercliffed him ex: Gaara,Naruto(jutsu clash/chakra intensity), and ofc Itachi

Once he took the drugs he became ridiculously powerful and reached his peak in shippuden/Boruto

Can he reach that on his own merit?