HX stomp to Fender FR10

Hi all, I just finally went for a HX stomp paired with a Fender FR10 for which I am pretty happy.

However with the thousand options the stomp has… what would be the best global settings in the stomp to get the best quality? I am referring to input levels and especially output levels (inst or line). Also, do you recommend any specific eq on the fender FR10 itself?

I also noticed that when I use the stomp with my Beyerdynamics 770 pro (80oh) it sounds… artificial?